Center for Tropical & Global Emerging Diseases

The Center for Tropical and Emerging Global Diseases (CTEGD) at The University of Georgia is one of the largest research centers focused on diseases of poverty. Based on a strong foundation of parasitology, immunology, cellular and molecular biology, biochemistry, and genetics, researchers and students work together on some of the most im- portant causes of human suffering around the world, including malaria, schistosomiasis, African sleeping sickness, Chagas disease, cryptosporidiosis, toxoplasmosis, filariasis, and leishmaniasis.

Many of these research programs have international, on-site components for both research and training. Currently, sites are located in South America, Africa, and Asia. Since 2004, CTEGD has housed a portion of the National Institutes of Health funded Bioinformatics Resource Center for Eukaryotic Pathogens, which is routinely accessed by over 13,000 researchers globally to study genomic and other high-throughput data related to significant human and veterinary pathogens.

Major goals of CTEGD include turning research into medical and public health interventions, promoting global research and edu- cation at the university and throughout the state of Georgia, and developing additional international research and education programs.

CTEGD FACULTY FOCUS

Ynes Ortega, Ph.D.

Two recent and significant outbreaks of Cyclospora infection in produce grown in the United States inspired Ynes Ortega, member of the Center for Tropical and Emerging Global Diseases and associate professor in the Department of Food Science and Technology’s Center for Food Safety, to focus her research on the Cyclospora parasite and its effect in
the country. Cyclospora is usually only found in imported vegetables, particularly salad greens, making the outbreak in 2018 unusual and dangerous.

Cyclospora cayetanensis, the single-cell parasite that causes cyclosporiasis, was first described by Ortega in the 1990s. A person becomes infected with the parasite by consuming contaminated food, which results in gastrointestinal illness characterized primarily by diarrhea. Cyclosporiasis is treated with sulfa drugs, fluids, and rest. If left untreated, the symptoms can persist for up to a month and can be recurring.

Ortega has been awarded a 2-year grant from the Center for Produce Safety, a non-profit organization committed to addressing issues faced by the produce industry, to investigate C. cayetanensis presence in the United States.

“We will be testing surface water for the presence of Cyclospora cayetanensis, improving sample collection methods, and genotyping of the parasite,” said Ortega.

This professor is working to study the origin of the parasite in the U.S. in order to reduce the number of domestic cases of cyclosporiasis, keeping people healthier.

CTEGD FACULTY FOCUS

Tania Rozario, Ph.D.

University of Georgia faculty member Tania Rozario has received a $2 million grant from the National Institutes of Health Director’s New Innovator Award Program, which supports early-career investigators of exceptional creativity who propose high-risk, high-reward research projects.
Rozario is an assistant professor with a joint appointment in the Franklin College of Arts and Sciences Department of Genetics and the Center for Tropical and Emerging Global Diseases.
Taking advantage of both extensive past research and the much more sophisticated tools of today, Rozario envisions a melding of developmental biology with parasitology as a new approach to understand parasitic flatworms. She is using
the rat tapeworm, Hymenolepis diminuta, to re-establish
a model organism that had been a favorite model among parasitologists in the early-mid 20th century but was left behind by the molecular biology revolution. Flatworms have incredible capacity for regeneration, according to Rozario, who studies them as agents of parasitic disease.
Rozario’s work is pioneering a new age for research in regenerative biology and how it interacts with global tropical diseases. Worms are largely overlooked in the study of disease agents but the assistant professor is channeling her resources to change that.
“It’s important that we study the monsters in our midst
so that we can learn from organisms in our environment that have these really out-there, unique physiological capabilities,” Rozario said. “We can learn about how they have evolved strategies to thrive in their specific niche, but they can also teach us something more fundamental about biology that could be broadly applicable.”

Faculty & Areas of Expertise

  • Mark Brown

    Structure and function of peptide hor- mones in mosquitos

    mrbrown@uga.edu

  • M. Belen Cassera

    Antimalarial drug discovery, natural products, metabolomics

    maria.cassera@uga.edu

  • Donald Champagne

    Vector biology, salivary factors

    dchampa@uga.edu

  • Roberto Docampo

    Metabolic pathways, trypanosomes

    rdocampo@uga.edu

  • Drew Etheridge

    Host-parasite interface, Toxoplasma gondii

    ronald.etheridge@uga.edu

  • Stephen Hajduk

    Molecular and biochemical basis of para- sitic diseases

    shajduk@uga.edu

  • Donald Harn

    Vaccine development, schistosomiasis

    dharn@uga.edu

  • Diego Huet

    Metabolomics and CRISPR-based approaches to understand the mitochon- drial and organellar biology of a class of protozoan parasites, the apicomplexans

    diego.huet@uga.edu

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